Human Glioblastoma Multiforme: p53 Reactivation by a Novel MDM2 Inhibitor

Cancer development and chemo-resistance are often due to impaired functioning of the p53 tumor suppressor through genetic mutation or sequestration by other proteins. In glioblastoma multiforme (GBM), p53 availability is frequently reduced because it binds to the Murine Double Minute-2 (MDM2) oncopr...

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Библиографические подробности
Главные авторы: Costa, Barbara, Bendinelli, Sara, Gabelloni, Pamela, Da Pozzo, Eleonora, Daniele, Simona, Scatena, Fabrizio, Vanacore, Renato, Campiglia, Pietro, Bertamino, Alessia, Gomez-Monterrey, Isabel, Sorriento, Daniela, Del Giudice, Carmine, Iaccarino, Guido, Novellino, Ettore, Martini, Claudia
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2013
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3747081/
https://ncbi.nlm.nih.gov/pubmed/23977270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072281
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