Combined inhibition of AKT/mTOR and MDM2 enhances Glioblastoma Multiforme cell apoptosis and differentiation of cancer stem cells

The poor prognosis of Glioblastoma Multiforme (GBM) is due to a high resistance to conventional treatments and to the presence of a subpopulation of glioma stem cells (GSCs). Combination therapies targeting survival/self-renewal signals of GBM and GSCs are emerging as useful tools to improve GBM tre...

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Опубликовано в: :Sci Rep
Главные авторы: Daniele, Simona, Costa, Barbara, Zappelli, Elisa, Da Pozzo, Eleonora, Sestito, Simona, Nesi, Giulia, Campiglia, Pietro, Marinelli, Luciana, Novellino, Ettore, Rapposelli, Simona, Martini, Claudia
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2015
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4404683/
https://ncbi.nlm.nih.gov/pubmed/25898313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09956
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