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Oligonucleotide transition state analogues of saporin L3
Ribosome inactivating proteins (RIPs) are among the most toxic agents known. More than a dozen clinical trials against refractory cancers have been initiated using modified RIPs with impressive results. However, dose-limiting toxicity due to vascular leak syndrome limits success of the therapy. We h...
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| Publicado no: | Eur J Med Chem |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5296225/ https://ncbi.nlm.nih.gov/pubmed/27823883 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2016.10.059 |
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