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Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins
Ricin A-chain (RTA) and saporin-L1 (SAP) catalyze adenosine depurination of 28S rRNA to inhibit protein synthesis and cause cell death. We present the crystal structures of RTA and SAP in complex with transition state analogue inhibitors. These tight-binding inhibitors mimic the sarcin–ricin recogni...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2787146/ https://ncbi.nlm.nih.gov/pubmed/19920175 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911606106 |
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