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Four generations of transition-state analogues for human purine nucleoside phosphorylase
Inhibition of human purine nucleoside phosphorylase (PNP) stops growth of activated T-cells and the formation of 6-oxypurine bases, making it a target for leukemia, autoimmune disorders, and gout. Four generations of ribocation transition-state mimics bound to PNP are structurally characterized. Imm...
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| Hlavní autoři: | , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2841916/ https://ncbi.nlm.nih.gov/pubmed/20212140 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913439107 |
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