Inhibition and structure of Trichomonas vaginalis purine nucleoside phosphorylase with picomolar transition state analogues

Trichomonas vaginalis is a parasitic protozoan purine auxotroph possessing a unique purine salvage pathway consisting of a bacterial type purine nucleoside phosphorylase (PNP) and a purine nucleoside kinase. Thus, T. vaginalis PNP (TvPNP) functions in the reverse direction relative to PNPs in other...

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Bibliographic Details
Main Authors: Rinaldo-Matthis, Agnes, Wing, Corin, Ghanem, Mahmoud, Deng, Hua, Wu, Peng, Gupta, Arti, Tyler, Peter C., Evans, Gary B., Furneaux, Richard H., Almo, Steven C., Wang, Ching C., Schramm, Vern L.
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2517847/
https://ncbi.nlm.nih.gov/pubmed/17223688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi061515r
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