Altered Enthalpy-Entropy Compensation in Picomolar Transition State Analogues of Human Purine Nucleoside Phosphorylase

Human purine nucleoside phosphorylase (PNP) belongs to the trimeric class of PNPs and is essential for catabolism of deoxyguanosine. Genetic deficiency of PNP in humans causes a specific T-cell immune deficiency and transition state analogue inhibitors of PNP are in development for treatment of T-ce...

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Hlavní autoři: Edwards, Achelle A., Mason, Jennifer M., Clinch, Keith, Tyler, Peter C., Evans, Gary B., Schramm, Vern L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711852/
https://ncbi.nlm.nih.gov/pubmed/19425594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi9005896
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