Conformational States of Human Purine Nucleoside Phosphorylase at Rest, at Work and with Transition State Analogues

Human purine nucleoside phosphorylase (PNP) is a homotrimer binding tightly to the transition state analogues Immucillin-H (ImmH, K(d) = 56 pM) and DATMe-ImmH-Immucillin-H (DATMe-ImmH, K(d) = 8.6 pM). ImmH binds with a larger entropic penalty than DATMe-ImmH, a chemically more flexible inhibitor. Th...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Edwards, Achelle A., Tipton, Jeremiah D., Brenowitz, Michael D., Emmett, Mark R., Marshall, Alan G., Evans, Gary B., Tyler, Peter C., Schramm, Vern L.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2010
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832846/
https://ncbi.nlm.nih.gov/pubmed/20108972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi902041j
टैग : टैग जोड़ें
कोई टैग नहीं, इस रिकॉर्ड को टैग करने वाले पहले व्यक्ति बनें!

समान संसाधन