Conformational States of Human Purine Nucleoside Phosphorylase at Rest, at Work and with Transition State Analogues

Human purine nucleoside phosphorylase (PNP) is a homotrimer binding tightly to the transition state analogues Immucillin-H (ImmH, K(d) = 56 pM) and DATMe-ImmH-Immucillin-H (DATMe-ImmH, K(d) = 8.6 pM). ImmH binds with a larger entropic penalty than DATMe-ImmH, a chemically more flexible inhibitor. Th...

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Autori principali: Edwards, Achelle A., Tipton, Jeremiah D., Brenowitz, Michael D., Emmett, Mark R., Marshall, Alan G., Evans, Gary B., Tyler, Peter C., Schramm, Vern L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832846/
https://ncbi.nlm.nih.gov/pubmed/20108972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi902041j
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