l-Enantiomers of Transition State Analogue Inhibitors Bound to Human Purine Nucleoside Phosphorylase

Human purine nucleoside phosphorylase (PNP) was crystallized with transition state analogue inhibitors Immucillin-H and DADMe-Immucillin-H synthesized with ribosyl mimics of l-stereochemistry. The inhibitors demonstrate that major driving forces for tight binding of these analogues are the leaving g...

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Main Authors: Rinaldo-Matthis, Agnes, Murkin, Andrew S., Ramagopal, Udupi A., Clinch, Keith, Mee, Simon P. H., Evans, Gary B., Tyler, Peter C., Furneaux, Richard H., Almo, Steven C., Schramm, Vern L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2531256/
https://ncbi.nlm.nih.gov/pubmed/18154341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja710733g
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