Crystal Structures of Leukotriene C(4) Synthase in Complex with Product Analogs: IMPLICATIONS FOR THE ENZYME MECHANISM

Por Niegowski, Damian, Kleinschmidt, Thea, Olsson, Ulrika, Ahmad, Shabbir, Rinaldo-Matthis, Agnes, Haeggström, Jesper Z.
Publicado em 2014

Neighboring Group Participation in the Transition State of Human Purine Nucleoside Phosphorylase

Por Murkin, Andrew S., Birck, Matthew R., Rinaldo-Matthis, Agnes, Shi, Wuxian, Taylor, Erika A., Schramm, Vern L.
Publicado em 2007

Transition state analogues of 5′-methylthioadenosine nucleosidase disrupt quorum sensing

Por Gutierrez, Jemy A., Crowder, Tamara, Rinaldo-Matthis, Agnes, Ho, Meng-Chiao, Almo, Steven C., Schramm, Vern L.
Publicado em 2009

Structure and Inhibition of Mouse Leukotriene C(4) Synthase

Por Niegowski, Damian, Kleinschmidt, Thea, Ahmad, Shabbir, Qureshi, Abdul Aziz, Mårback, Michaela, Rinaldo-Matthis, Agnes, Haeggström, Jesper Z.
Publicado em 2014

Structural and Functional Analysis of Calcium Ion Mediated Binding of 5-Lipoxygenase to Nanodiscs

Por Kumar, Ramakrishnan B., Zhu, Lin, Idborg, Helena, Rådmark, Olof, Jakobsson, Per-Johan, Rinaldo-Matthis, Agnes, Hebert, Hans, Jegerschöld, Caroline
Publicado no PLoS One (2016)

A High Affinity Adenosine Kinase from Anopheles gambiae

Por Cassera, María B., Ho, Meng-Chiao, Merino, Emilio F., Burgos, Emmanuel S., Rinaldo-Matthis, Agnes, Almo, Steven C., Schramm, Vern L.
Publicado em 2011

A dynamic Asp–Arg interaction is essential for catalysis in microsomal prostaglandin E(2) synthase

Por Brock, Joseph S., Hamberg, Mats, Balagunaseelan, Navisraj, Goodman, Michael, Morgenstern, Ralf, Strandback, Emilia, Samuelsson, Bengt, Rinaldo-Matthis, Agnes, Haeggström, Jesper Z.
Publicado no Proc Natl Acad Sci U S A (2016)

Arginine 104 Is a Key Catalytic Residue in Leukotriene C(4) Synthase

Por Rinaldo-Matthis, Agnes, Wetterholm, Anders, Molina, Daniel Martinez, Holm, Johanna, Niegowski, Damian, Ohlson, Eva, Nordlund, Pär, Morgenstern, Ralf, Haeggström, Jesper Z.
Publicado em 2010

Binding of Pro-Gly-Pro at the active site of leukotriene A(4) hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor

Por Stsiapanava, Alena, Olsson, Ulrika, Wan, Min, Kleinschmidt, Thea, Rutishauser, Dorothea, Zubarev, Roman A., Samuelsson, Bengt, Rinaldo-Matthis, Agnes, Haeggström, Jesper Z.
Publicado em 2014

Phosphorylation of Leukotriene C(4) Synthase at Serine 36 Impairs Catalytic Activity

Por Ahmad, Shabbir, Ytterberg, A. Jimmy, Thulasingam, Madhuranayaki, Tholander, Fredrik, Bergman, Tomas, Zubarev, Roman, Wetterholm, Anders, Rinaldo-Matthis, Agnes, Haeggström, Jesper Z.
Publicado no J Biol Chem (2016)

Four generations of transition-state analogues for human purine nucleoside phosphorylase

Por Ho, Meng-Chiao, Shi, Wuxian, Rinaldo-Matthis, Agnes, Tyler, Peter C., Evans, Gary B., Clinch, Keith, Almo, Steven C., Schramm, Vern L.
Publicado em 2010

l-Enantiomers of Transition State Analogue Inhibitors Bound to Human Purine Nucleoside Phosphorylase

Por Rinaldo-Matthis, Agnes, Murkin, Andrew S., Ramagopal, Udupi A., Clinch, Keith, Mee, Simon P. H., Evans, Gary B., Tyler, Peter C., Furneaux, Richard H., Almo, Steven C., Schramm, Vern L.
Publicado em 2007

A picomolar transition state analogue inhibitor of MTAN as a specific antibiotic for H. pylori

Por Wang, Shanzhi, Haapalainen, Antti M., Yan, Funing, Du, Quan, Tyler, Peter C., Evans, Gary B., Rinaldo-Matthis, Agnes, Brown, Rosemary L., Norris, Gillian E., Almo, Steven C., Schramm, Vern L.
Publicado em 2012

Catalytic Conversion of Lipophilic Substrates by Phase constrained Enzymes in the Aqueous or in the Membrane Phase

Por Cebula, Marcus, Turan, Ilke Simsek, Sjödin, Birgitta, Thulasingam, Madhuranayaki, Brock, Joseph, Chmyrov, Volodymyr, Widengren, Jerker, Abe, Hiroshi, Mannervik, Bengt, Haeggström, Jesper Z., Rinaldo-Matthis, Agnes, Akkaya, Engin U., Morgenstern, Ralf
Publicado no Sci Rep (2016)

Inhibition and structure of Trichomonas vaginalis purine nucleoside phosphorylase with picomolar transition state analogues

Por Rinaldo-Matthis, Agnes, Wing, Corin, Ghanem, Mahmoud, Deng, Hua, Wu, Peng, Gupta, Arti, Tyler, Peter C., Evans, Gary B., Furneaux, Richard H., Almo, Steven C., Wang, Ching C., Schramm, Vern L.
Publicado em 2007