Arginine 104 Is a Key Catalytic Residue in Leukotriene C(4) Synthase

Human leukotriene C(4) synthase (hLTC(4)S) is an integral membrane enzyme that conjugates leukotriene (LT) A(4) with glutathione to form LTC(4), a precursor to the cysteinyl leukotrienes (LTC(4), LTD(4), and LTE(4)) that are involved in the pathogenesis of human bronchial asthma. From the crystal st...

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Bibliographische Detailangaben
Hauptverfasser: Rinaldo-Matthis, Agnes, Wetterholm, Anders, Molina, Daniel Martinez, Holm, Johanna, Niegowski, Damian, Ohlson, Eva, Nordlund, Pär, Morgenstern, Ralf, Haeggström, Jesper Z.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Enzymology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003377/
https://ncbi.nlm.nih.gov/pubmed/20980252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.105940
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