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Crystal Structures of Leukotriene C(4) Synthase in Complex with Product Analogs: IMPLICATIONS FOR THE ENZYME MECHANISM
Leukotriene (LT) C(4) synthase (LTC4S) catalyzes the conjugation of the fatty acid LTA(4) with the tripeptide GSH to produce LTC(4), the parent compound of the cysteinyl leukotrienes, important mediators of asthma. Here we mutated Trp-116 in human LTC4S, a residue proposed to play a key role in subs...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3931076/ https://ncbi.nlm.nih.gov/pubmed/24366866 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.534628 |
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