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Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis

Microsomal glutathione S-transferase 2 (MGST2) produces leukotriene C(4), key for intracrine signaling of endoplasmic reticulum (ER) stress, oxidative DNA damage and cell death. MGST2 trimer restricts catalysis to only one out of three active sites at a time, but the molecular basis is unknown. Here...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Thulasingam, Madhuranayaki, Orellana, Laura, Nji, Emmanuel, Ahmad, Shabbir, Rinaldo-Matthis, Agnes, Haeggström, Jesper Z.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7979937/
https://ncbi.nlm.nih.gov/pubmed/33741927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21924-8
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