Phosphorylation of Leukotriene C(4) Synthase at Serine 36 Impairs Catalytic Activity

Leukotriene C(4) synthase (LTC4S) catalyzes the formation of the proinflammatory lipid mediator leukotriene C(4) (LTC(4)). LTC(4) is the parent molecule of the cysteinyl leukotrienes, which are recognized for their pathogenic role in asthma and allergic diseases. Cellular LTC4S activity is suppresse...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Ahmad, Shabbir, Ytterberg, A. Jimmy, Thulasingam, Madhuranayaki, Tholander, Fredrik, Bergman, Tomas, Zubarev, Roman, Wetterholm, Anders, Rinaldo-Matthis, Agnes, Haeggström, Jesper Z.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5000086/
https://ncbi.nlm.nih.gov/pubmed/27365393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.735647
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