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A dynamic Asp–Arg interaction is essential for catalysis in microsomal prostaglandin E(2) synthase
Microsomal prostaglandin E(2) synthase type 1 (mPGES-1) is responsible for the formation of the potent lipid mediator prostaglandin E(2) under proinflammatory conditions, and this enzyme has received considerable attention as a drug target. Recently, a high-resolution crystal structure of human mPGE...
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| Τόπος έκδοσης: | Proc Natl Acad Sci U S A |
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| Κύριοι συγγραφείς: | , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
National Academy of Sciences
2016
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4743789/ https://ncbi.nlm.nih.gov/pubmed/26755582 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1522891113 |
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