Mutation of a Critical Arginine in Microsomal Prostaglandin E Synthase-1 Shifts the Isomerase Activity to a Reductase Activity That Converts Prostaglandin H(2) into Prostaglandin F(2α)

Microsomal prostaglandin E synthase type 1 (mPGES-1) converts prostaglandin endoperoxides, generated from arachidonic acid by cyclooxygenases, into prostaglandin E(2). This enzyme belongs to the membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG) family of integral membrane...

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Detalhes bibliográficos
Main Authors: Hammarberg, Tove, Hamberg, Mats, Wetterholm, Anders, Hansson, Henrik, Samuelsson, Bengt, Haeggström, Jesper Z.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Enzyme Catalysis and Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2610511/
https://ncbi.nlm.nih.gov/pubmed/18984580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808365200
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