A dynamic Asp–Arg interaction is essential for catalysis in microsomal prostaglandin E(2) synthase

Microsomal prostaglandin E(2) synthase type 1 (mPGES-1) is responsible for the formation of the potent lipid mediator prostaglandin E(2) under proinflammatory conditions, and this enzyme has received considerable attention as a drug target. Recently, a high-resolution crystal structure of human mPGE...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Brock, Joseph S., Hamberg, Mats, Balagunaseelan, Navisraj, Goodman, Michael, Morgenstern, Ralf, Strandback, Emilia, Samuelsson, Bengt, Rinaldo-Matthis, Agnes, Haeggström, Jesper Z.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4743789/
https://ncbi.nlm.nih.gov/pubmed/26755582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1522891113
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