Binding of Pro-Gly-Pro at the active site of leukotriene A(4) hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor

Leukotriene (LT) A(4) hydrolase/aminopeptidase (LTA4H) is a bifunctional zinc metalloenzyme that catalyzes the committed step in the formation of the proinflammatory mediator LTB(4). Recently, the chemotactic tripeptide Pro-Gly-Pro was identified as an endogenous aminopeptidase substrate for LTA(4)...

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Библиографические подробности
Главные авторы: Stsiapanava, Alena, Olsson, Ulrika, Wan, Min, Kleinschmidt, Thea, Rutishauser, Dorothea, Zubarev, Roman A., Samuelsson, Bengt, Rinaldo-Matthis, Agnes, Haeggström, Jesper Z.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2014
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3964119/
https://ncbi.nlm.nih.gov/pubmed/24591641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1402136111
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