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Capturing LTA(4) hydrolase in action: Insights to the chemistry and dynamics of chemotactic LTB(4) synthesis
Human leukotriene (LT) A(4) hydrolase/aminopeptidase (LTA(4)H) is a bifunctional enzyme that converts the highly unstable epoxide intermediate LTA(4) into LTB(4), a potent leukocyte activating agent, while the aminopeptidase activity cleaves and inactivates the chemotactic tripeptide Pro-Gly-Pro. He...
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| Yayımlandı: | Proc Natl Acad Sci U S A |
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| Asıl Yazarlar: | , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
National Academy of Sciences
2017
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5594697/ https://ncbi.nlm.nih.gov/pubmed/28827365 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1710850114 |
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