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Capturing LTA(4) hydrolase in action: Insights to the chemistry and dynamics of chemotactic LTB(4) synthesis

Human leukotriene (LT) A(4) hydrolase/aminopeptidase (LTA(4)H) is a bifunctional enzyme that converts the highly unstable epoxide intermediate LTA(4) into LTB(4), a potent leukocyte activating agent, while the aminopeptidase activity cleaves and inactivates the chemotactic tripeptide Pro-Gly-Pro. He...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Stsiapanava, Alena, Samuelsson, Bengt, Haeggström, Jesper Z.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2017
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5594697/
https://ncbi.nlm.nih.gov/pubmed/28827365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1710850114
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