The Catalytic Architecture of Leukotriene C(4) Synthase with Two Arginine Residues

Leukotriene (LT) C(4) and its metabolites, LTD(4) and LTE(4), are involved in the pathobiology of bronchial asthma. LTC(4) synthase is the nuclear membrane-embedded enzyme responsible for LTC(4) biosynthesis, catalyzing the conjugation of two substrates that have considerably different water solubil...

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Detalhes bibliográficos
Main Authors: Saino, Hiromichi, Ukita, Yoko, Ago, Hideo, Irikura, Daisuke, Nisawa, Atsushi, Ueno, Go, Yamamoto, Masaki, Kanaoka, Yoshihide, Lam, Bing K., Austen, K. Frank, Miyano, Masashi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3091245/
https://ncbi.nlm.nih.gov/pubmed/21454538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.150177
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