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A leukotriene C(4) synthase inhibitor with the backbone of 5-(5-methylene-4-oxo-4,5-dihydrothiazol-2-ylamino) isophthalic acid
The cysteinyl leukotrienes (cys-LTs), leukotriene C(4) (LTC(4)) and its metabolites, LTD(4) and LTE(4), are proinflammatory lipid mediators in asthma and other inflammatory diseases. They are generated through the 5-lipoxygenase/LTC(4) synthase (LTC(4)S) pathway and act via at least two distinct G p...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3635087/ https://ncbi.nlm.nih.gov/pubmed/23378248 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jb/mvt007 |
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