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GPR17 is a negative regulator of the cysteinyl leukotriene 1 receptor response to leukotriene D(4)
The cysteinyl leukotrienes (cys-LTs) are proinflammatory lipid mediators acting on the type 1 cys-LT receptor (CysLT(1)R) to mediate smooth muscle constriction and vascular permeability. GPR17, a G protein-coupled orphan receptor with homology to the P2Y and cys-LT receptors, failed to mediate calci...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2710631/ https://ncbi.nlm.nih.gov/pubmed/19561298 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0905364106 |
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