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GPR17 is a negative regulator of the cysteinyl leukotriene 1 receptor response to leukotriene D(4)

The cysteinyl leukotrienes (cys-LTs) are proinflammatory lipid mediators acting on the type 1 cys-LT receptor (CysLT(1)R) to mediate smooth muscle constriction and vascular permeability. GPR17, a G protein-coupled orphan receptor with homology to the P2Y and cys-LT receptors, failed to mediate calci...

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Détails bibliographiques
Auteurs principaux: Maekawa, Akiko, Balestrieri, Barbara, Austen, K. Frank, Kanaoka, Yoshihide
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2710631/
https://ncbi.nlm.nih.gov/pubmed/19561298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0905364106
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