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Cysteinyl leukotriene 1 receptor controls the severity of chronic pulmonary inflammation and fibrosis

The cysteinyl leukotrienes (cys-LTs), leukotriene (LT) C(4), LTD(4), and LTE(4), are smooth muscle constrictors that signal via the CysLT(1) receptor. Here we report that the cys-LTs play an important role in chronic pulmonary inflammation with fibrosis induced by bleomycin in mice. Targeted disrupt...

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Main Authors: Beller, Thomas C., Friend, Daniel S., Maekawa, Akiko, Lam, Bing K., Austen, K. Frank, Kanaoka, Yoshihide
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2004
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC365742/
https://ncbi.nlm.nih.gov/pubmed/14970333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400235101
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