Small Molecule Inhibitors of Protein Arginine Methyltransferases

Por Hu, Hao, Qian, Kun, Ho, Meng-Chiao, Zheng, Y. George
Publicado no Expert Opin Investig Drugs (2016)

A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT

Por Burgos, Emmanuel S., Ho, Meng-Chiao, Almo, Steven C., Schramm, Vern L.
Publicado em 2009

Methylthioinosine Phosphorylase from Pseudomonas aeruginosa. Structure and Annotation of a Novel Enzyme in Quorum Sensing

Por Guan, Rong, Ho, Meng-Chiao, Almo, Steven C., Schramm, Vern L.
Publicado em 2011

Characterizing DNA Methyltransferases With An Ultrasensitive Luciferase-Linked Continuous Assay

Por Hemeon, Ivan, Gutierrez, Jemy A., Ho, Meng-Chiao, Schramm, Vern L.
Publicado em 2011

Investigation of Catalytic Loop Structure, Dynamics and Function Relationship of Yersinia Protein Tyrosine Phosphatase by Temperature-Jump Relaxation Spectroscopy and X-ray Structu...

Por Ke, Shan, Ho, Meng-Chiao, Zhadin, Nickolay, Deng, Hua, Callender, Robert
Publicado em 2012

Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins

Por Ho, Meng-Chiao, Sturm, Matthew B., Almo, Steven C., Schramm, Vern L.
Publicado em 2009

Transition state analogues of 5′-methylthioadenosine nucleosidase disrupt quorum sensing

Por Gutierrez, Jemy A., Crowder, Tamara, Rinaldo-Matthis, Agnes, Ho, Meng-Chiao, Almo, Steven C., Schramm, Vern L.
Publicado em 2009

Methylthioadenosine Deaminase in an Alternative Quorum Sensing Pathway in Pseudomonas aeruginosa

Por Guan, Rong, Ho, Meng-Chiao, Frohlich, Richard F.G., Tyler, Peter C., Almo, Steven C., Schramm, Vern L.
Publicado em 2012

Entropy-Driven Binding of Picomolar Transition State Analogue Inhibitors to Human 5′-Methylthioadenosine Phosphorylase()

Por Guan, Rong, Ho, Meng-Chiao, Brenowitz, Michael, Tyler, Peter C., Evans, Gary B., Almo, Steven C., Schramm, Vern L.
Publicado em 2011

A High Affinity Adenosine Kinase from Anopheles gambiae

Por Cassera, María B., Ho, Meng-Chiao, Merino, Emilio F., Burgos, Emmanuel S., Rinaldo-Matthis, Agnes, Almo, Steven C., Schramm, Vern L.
Publicado em 2011

Four generations of transition-state analogues for human purine nucleoside phosphorylase

Por Ho, Meng-Chiao, Shi, Wuxian, Rinaldo-Matthis, Agnes, Tyler, Peter C., Evans, Gary B., Clinch, Keith, Almo, Steven C., Schramm, Vern L.
Publicado em 2010

Structural and metabolic specificity of methylthiocoformycin for malarial adenosine deaminases

Por Ho, Meng-Chiao, Cassera, María B., Madrid, Dennis C., Ting, Li-Min, Tyler, Peter C., Kim, Kami, Almo, Steven C., Schramm, Vern L.
Publicado em 2009

Diamidine Compounds for Selective Inhibition of Protein Arginine Methyltransferase 1

Por Yan, Leilei, Yan, Chunli, Qian, Kun, Su, Hairui, Kofsky-Wofford, Stephanie A., Lee, Wei-Chao, Zhao, Xinyang, Ho, Meng-Chiao, Ivanov, Ivaylo, Zheng, Yujun George
Publicado em 2014

Acyclic Immucillin Phosphonates: Second generation inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase

Por Hazleton, Keith Z., Ho, Meng-Chiao, Cassera, Maria B., Clinch, Keith, Crump, Douglas R., Rosario, Irving, Merino, Emilio F., Almo, Steve C., Tyler, Peter C., Schramm, Vern L.
Publicado em 2012

Inhibition and Structure of Toxoplasma gondii Purine Nucleoside Phosphorylase

Por Donaldson, Teraya M., Cassera, María B., Ho, Meng-Chiao, Zhan, Chenyang, Merino, Emilio F., Evans, Gary B., Tyler, Peter C., Almo, Steven C., Schramm, Vern L., Kim, Kami
Publicado em 2014

Plasmodium falciparum Parasites Are Killed by a Transition State Analogue of Purine Nucleoside Phosphorylase in a Primate Animal Model

Por Cassera, María B., Hazleton, Keith Z., Merino, Emilio F., Obaldia, Nicanor, Ho, Meng-Chiao, Murkin, Andrew S., DePinto, Richard, Gutierrez, Jemy A., Almo, Steven C., Evans, Gary B., Babu, Yarlagadda S., Schramm, Vern L.
Publicado em 2011

Biochemical Characterization and Structural Analysis of a Bifunctional Cellulase/Xylanase from Clostridium thermocellum

Por Yuan, Shuo-Fu, Wu, Tzu-Hui, Lee, Hsiao-Lin, Hsieh, Han-Yu, Lin, Wen-Ling, Yang, Barbara, Chang, Chih-Kang, Li, Qian, Gao, Jian, Huang, Chun-Hsiang, Ho, Meng-Chiao, Guo, Rey-Ting, Liang, Po-Huang
Publicado no J Biol Chem (2015)

Structure of the Arginine Methyltransferase PRMT5-MEP50 Reveals a Mechanism for Substrate Specificity

Por Ho, Meng-Chiao, Wilczek, Carola, Bonanno, Jeffrey B., Xing, Li, Seznec, Janina, Matsui, Tsutomu, Carter, Lester G., Onikubo, Takashi, Kumar, P. Rajesh, Chan, Man K., Brenowitz, Michael, Cheng, R. Holland, Reimer, Ulf, Almo, Steven C., Shechter, David
Publicado em 2013

Correction: Structure of the Arginine Methyltransferase PRMT5-MEP50 Reveals a Mechanism for Substrate Specificity

Por Ho, Meng-Chiao, Wilczek, Carola, Bonanno, Jeffrey B., Xing, Li, Seznec, Janina, Matsui, Tsutomu, Carter, Lester G., Onikubo, Takashi, Kumar, P. Rajesh, Chan, Man K., Brenowitz, Michael, Cheng, R. Holland, Reimer, Ulf, Almo, Steven C., Shechter, David
Publicado em 2013