Structure of the Arginine Methyltransferase PRMT5-MEP50 Reveals a Mechanism for Substrate Specificity

The arginine methyltransferase PRMT5-MEP50 is required for embryogenesis and is misregulated in many cancers. PRMT5 targets a wide variety of substrates, including histone proteins involved in specifying an epigenetic code. However, the mechanism by which PRMT5 utilizes MEP50 to discriminate substra...

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Bibliografski detalji
Glavni autori: Ho, Meng-Chiao, Wilczek, Carola, Bonanno, Jeffrey B., Xing, Li, Seznec, Janina, Matsui, Tsutomu, Carter, Lester G., Onikubo, Takashi, Kumar, P. Rajesh, Chan, Man K., Brenowitz, Michael, Cheng, R. Holland, Reimer, Ulf, Almo, Steven C., Shechter, David
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581573/
https://ncbi.nlm.nih.gov/pubmed/23451136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0057008
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