A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT
Nicotinamide phosphoribosyltransferase (NAMPT) is highly evolved to capture nicotinamide (NAM) and replenish the nicotinamide adenine dinucleotide (NAD(+)) pool during ADP-ribosylation and transferase reactions. ATP-phosphorylation of an active-site histidine causes catalytic activation, increasing...
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Main Authors: | , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
National Academy of Sciences
2009
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2728965/ https://ncbi.nlm.nih.gov/pubmed/19666527 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903898106 |
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