A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT

Nicotinamide phosphoribosyltransferase (NAMPT) is highly evolved to capture nicotinamide (NAM) and replenish the nicotinamide adenine dinucleotide (NAD(+)) pool during ADP-ribosylation and transferase reactions. ATP-phosphorylation of an active-site histidine causes catalytic activation, increasing...

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Detalhes bibliográficos
Main Authors: Burgos, Emmanuel S., Ho, Meng-Chiao, Almo, Steven C., Schramm, Vern L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2728965/
https://ncbi.nlm.nih.gov/pubmed/19666527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903898106
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https://ncbi.nlm.nih.gov/pmc/articles/PMC2728965/
https://ncbi.nlm.nih.gov/pubmed/19666527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903898106