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Catalytic Site Conformations in Human PNP by (19)F-NMR and Crystallography
Purine nucleoside phosphorylase (PNP) is a target for leukemia, gout and autoimmune disorders. Dynamic motion of catalytic site loops has been implicated in catalysis, but experimental evidence was lacking. We replaced catalytic site groups His257 or His64 with 6-fluoro-tryptophan (6FW) as site-spec...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3584414/ https://ncbi.nlm.nih.gov/pubmed/23438750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2013.01.009 |
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