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Leaving Group Activation and Pyrophosphate Ionic State at the Catalytic Site of Plasmodium falciparum Orotate Phosphoribosyltransferase

Plasmodium falciparum orotate phosphoribosyltransferase (PfOPRT) catalyzes the reversible pyrophosphorolysis of orotidine 5'-monophosphate (OMP). Transition state analysis from kinetic isotope effects supports a dianionic orotic acid (OA) leaving group. Isotope-edited Fourier transform infrared...

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Main Authors: Zhang, Yong, Deng, Hua, Schramm, Vern L.
格式: Artigo
語言:Inglês
出版: 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012390/
https://ncbi.nlm.nih.gov/pubmed/21067187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja107806j
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