Transition State Analogues of Plasmodium falciparum and Human Orotate Phosphoribosyltransferases

The survival and proliferation of Plasmodium falciparum parasites and human cancer cells require de novo pyrimidine synthesis to supply RNA and DNA precursors. Orotate phosphoribosyltransferase (OPRT) is an indispensible component in this metabolic pathway and is a target for antimalarials and antit...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Zhang, Yong, Evans, Gary B., Clinch, Keith, Crump, Douglas R., Harris, Lawrence D., Fröhlich, Richard F. G., Tyler, Peter C., Hazleton, Keith Z., Cassera, María B., Schramm, Vern L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2013
Pynciau:
Enzymology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843086/
https://ncbi.nlm.nih.gov/pubmed/24158442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.521955
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg