Transition State Analogues of Plasmodium falciparum and Human Orotate Phosphoribosyltransferases

The survival and proliferation of Plasmodium falciparum parasites and human cancer cells require de novo pyrimidine synthesis to supply RNA and DNA precursors. Orotate phosphoribosyltransferase (OPRT) is an indispensible component in this metabolic pathway and is a target for antimalarials and antit...

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Detalhes bibliográficos
Main Authors: Zhang, Yong, Evans, Gary B., Clinch, Keith, Crump, Douglas R., Harris, Lawrence D., Fröhlich, Richard F. G., Tyler, Peter C., Hazleton, Keith Z., Cassera, María B., Schramm, Vern L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843086/
https://ncbi.nlm.nih.gov/pubmed/24158442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.521955
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