Transition State Analogues of Plasmodium falciparum and Human Orotate Phosphoribosyltransferases

The survival and proliferation of Plasmodium falciparum parasites and human cancer cells require de novo pyrimidine synthesis to supply RNA and DNA precursors. Orotate phosphoribosyltransferase (OPRT) is an indispensible component in this metabolic pathway and is a target for antimalarials and antit...

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Bibliografiska uppgifter
Huvudupphovsmän: Zhang, Yong, Evans, Gary B., Clinch, Keith, Crump, Douglas R., Harris, Lawrence D., Fröhlich, Richard F. G., Tyler, Peter C., Hazleton, Keith Z., Cassera, María B., Schramm, Vern L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2013
Ämnen:
Enzymology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843086/
https://ncbi.nlm.nih.gov/pubmed/24158442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.521955
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