Transition State Analogues of Plasmodium falciparum and Human Orotate Phosphoribosyltransferases

The survival and proliferation of Plasmodium falciparum parasites and human cancer cells require de novo pyrimidine synthesis to supply RNA and DNA precursors. Orotate phosphoribosyltransferase (OPRT) is an indispensible component in this metabolic pathway and is a target for antimalarials and antit...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Zhang, Yong, Evans, Gary B., Clinch, Keith, Crump, Douglas R., Harris, Lawrence D., Fröhlich, Richard F. G., Tyler, Peter C., Hazleton, Keith Z., Cassera, María B., Schramm, Vern L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2013
Gaiak:
Enzymology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843086/
https://ncbi.nlm.nih.gov/pubmed/24158442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.521955
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