טוען...
Transition State Analogues of Plasmodium falciparum and Human Orotate Phosphoribosyltransferases
The survival and proliferation of Plasmodium falciparum parasites and human cancer cells require de novo pyrimidine synthesis to supply RNA and DNA precursors. Orotate phosphoribosyltransferase (OPRT) is an indispensible component in this metabolic pathway and is a target for antimalarials and antit...
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| Main Authors: | , , , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
American Society for Biochemistry and Molecular Biology
2013
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3843086/ https://ncbi.nlm.nih.gov/pubmed/24158442 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.521955 |
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