Acyclic phosph(on)ate inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase

The pathogenic protozoa responsible for malaria lack enzymes for the de novo synthesis of purines and rely on purine salvage from the host. In Plasmodium falciparum (Pf), hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT) converts hypoxanthine to inosine monophosphate and is essential...

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Autors principals: Clinch, Keith, Crump, Douglas R., Evans, Gary B., Hazleton, Keith Z., Mason, Jennifer M., Schramm, Vern L., Tyler, Peter C.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740065/
https://ncbi.nlm.nih.gov/pubmed/23810424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.02.016
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