Evaluating Iso-Mukaadial Acetate and Ursolic Acid Acetate as Plasmodium falciparum Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase Inhibitors

To date, Plasmodium falciparum is one of the most lethal strains of the malaria parasite. P. falciparum lacks the required enzymes to create its own purines via the de novo pathway, thereby making Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPT) a crucial enzym...

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Dades bibliogràfiques
Publicat a:Biomolecules
Autors principals: Opoku, Francis, Govender, Penny P., Pooe, Ofentse J., Simelane, Mthokozisi B.C.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6995562/
https://ncbi.nlm.nih.gov/pubmed/31835879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom9120861
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