Evaluating Iso-Mukaadial Acetate and Ursolic Acid Acetate as Plasmodium falciparum Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase Inhibitors

To date, Plasmodium falciparum is one of the most lethal strains of the malaria parasite. P. falciparum lacks the required enzymes to create its own purines via the de novo pathway, thereby making Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPT) a crucial enzym...

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Bibliographic Details
Published in:Biomolecules
Main Authors: Opoku, Francis, Govender, Penny P., Pooe, Ofentse J., Simelane, Mthokozisi B.C.
Format: Artigo
Language:Inglês
Published: MDPI 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6995562/
https://ncbi.nlm.nih.gov/pubmed/31835879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom9120861
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