Kinetic Isotope Effects and Transition State Structure for Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase from Plasmodium falciparum

Plasmodium falciparum parasites are purine auxotrophs that rely exclusively on the salvage of preformed purines from their human hosts to supply the requirement for purine nucleotides. Hypoxanthine-guanine-xanthine phosphor-ibosyltransferase (HGXPRT) catalyzes the freely reversible Mg(2+)-dependent...

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Detaylı Bibliyografya
Yayımlandı:Biochemistry
Asıl Yazarlar: Ducati, Rodrigo G., Firestone, Ross S., Schramm, Vern L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5926801/
https://ncbi.nlm.nih.gov/pubmed/29131588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b01027
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