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Kinetic Isotope Effects and Transition State Structure for Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase from Plasmodium falciparum
Plasmodium falciparum parasites are purine auxotrophs that rely exclusively on the salvage of preformed purines from their human hosts to supply the requirement for purine nucleotides. Hypoxanthine-guanine-xanthine phosphor-ibosyltransferase (HGXPRT) catalyzes the freely reversible Mg(2+)-dependent...
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| Publicado en: | Biochemistry |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5926801/ https://ncbi.nlm.nih.gov/pubmed/29131588 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b01027 |
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