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Kinetic Isotope Effects and Transition State Structure for Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase from Plasmodium falciparum

Plasmodium falciparum parasites are purine auxotrophs that rely exclusively on the salvage of preformed purines from their human hosts to supply the requirement for purine nucleotides. Hypoxanthine-guanine-xanthine phosphor-ibosyltransferase (HGXPRT) catalyzes the freely reversible Mg(2+)-dependent...

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Bibliografski detalji
Izdano u:Biochemistry
Glavni autori: Ducati, Rodrigo G., Firestone, Ross S., Schramm, Vern L.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5926801/
https://ncbi.nlm.nih.gov/pubmed/29131588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b01027
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