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Kinetic Isotope Effects and Transition State Structure for Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase from Plasmodium falciparum

Plasmodium falciparum parasites are purine auxotrophs that rely exclusively on the salvage of preformed purines from their human hosts to supply the requirement for purine nucleotides. Hypoxanthine-guanine-xanthine phosphor-ibosyltransferase (HGXPRT) catalyzes the freely reversible Mg(2+)-dependent...

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Bibliografiske detaljer
Udgivet i:Biochemistry
Main Authors: Ducati, Rodrigo G., Firestone, Ross S., Schramm, Vern L.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5926801/
https://ncbi.nlm.nih.gov/pubmed/29131588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b01027
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