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Pyrophosphate Interactions at the Transition States of Plasmodium falciparum and Human Orotate Phosphoribosyltransferases
Orotate phosphoribosyltransferases from Plasmodium falciparum and human sources (PfOPRT and HsOPRT) use orotidine as a slow substrate in the pyrophosphorolysis reaction. With orotidine, intrinsic kinetic isotope effects (KIEs) can be measured for pyrophosphorolysis, providing the first use of pyroph...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2892240/ https://ncbi.nlm.nih.gov/pubmed/20527751 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja102849w |
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