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Structural and metabolic specificity of methylthiocoformycin for malarial adenosine deaminases
Plasmodium falciparum is a purine auxotroph requiring hypoxanthine as a key metabolic precursor. Erythrocyte adenine nucleotides are the source of the purine precursors, making adenosine deaminase (ADA) a key enzyme in the pathway of hypoxanthine formation. Methylthioadenosine (MTA) is a substrate f...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2771402/ https://ncbi.nlm.nih.gov/pubmed/19728741 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi9012484 |
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