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Synthesis of 5′-Methylthio Coformycins: Specific Inhibitors for Malarial Adenosine Deaminase
Transition state theory suggests that enzymatic rate acceleration (k(cat)/k(non)) is related to the stabilization of the transition state for a given reaction. Chemically stable analogues of a transition state complex are predicted to convert catalytic energy into binding energy. Since transition st...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2522312/ https://ncbi.nlm.nih.gov/pubmed/17488013 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja0708363 |
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