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Characterizing DNA Methyltransferases With An Ultrasensitive Luciferase-Linked Continuous Assay

DNA (cytosine-5)-methyltransferases (DNMTs) catalyze the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the 5-position of cytosine residues and thereby silence transcription of regulated genes. DNMTs are important epigenetic targets. However, isolated DNMTs are weak catalysts an...

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Hlavní autoři: Hemeon, Ivan, Gutierrez, Jemy A., Ho, Meng-Chiao, Schramm, Vern L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3115440/
https://ncbi.nlm.nih.gov/pubmed/21545095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac200816m
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