Transition state analogues of 5′-methylthioadenosine nucleosidase disrupt quorum sensing

5′-Methylthioadenosine nucleosidase (MTAN) is a bacterial enzyme involved in S-adenosylmethionine-related quorum sensing pathways that induce bacterial pathogenesis factors. Transition state analogues 5′-methylthio- (MT-), 5′-ethylthio- (EtT-) and 5′-butylthio- (BuT-) DADMe-ImmucillinAs are slow-ons...

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Autores principales: Gutierrez, Jemy A., Crowder, Tamara, Rinaldo-Matthis, Agnes, Ho, Meng-Chiao, Almo, Steven C., Schramm, Vern L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743263/
https://ncbi.nlm.nih.gov/pubmed/19270684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.153
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