Transition state analogues in quorum sensing and SAM recycling

Transition state structures can be derived from kinetic isotope effects and computational chemistry. Molecular electrostatic potential maps of transition states serve as blueprints to guide synthesis of transition state analogue inhibitors of target enzymes. 5’-Methylthioadenosine phosphorylase (MTA...

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Detalhes bibliográficos
Main Authors: Schramm, Vern L., Gutierrez, Jemy A., Cordovano, Grace, Basu, Indranil, Guha, Chandan, Belbin, Thomas J., Evans, Gary B., Tyler, Peter C., Furneaux, Richard H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2725438/
https://ncbi.nlm.nih.gov/pubmed/18776260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nass/nrn038
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