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Growth and Metastases of Human Lung Cancer Are Inhibited in Mouse Xenografts by a Transition State Analogue of 5′-Methylthioadenosine Phosphorylase

The S-adenosylmethionine (AdoMet) salvage enzyme 5′-methylthioadenosine phosphorylase (MTAP) has been implicated as both a cancer target and a tumor suppressor. We tested these hypotheses in mouse xenografts of human lung cancers. AdoMet recycling from 5′-methylthioadenosine (MTA) was blocked by inh...

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Hlavní autoři: Basu, Indranil, Locker, Joseph, Cassera, Maria B., Belbin, Thomas J., Merino, Emilio F., Dong, Xinyuan, Hemeon, Ivan, Evans, Gary B., Guha, Chandan, Schramm, Vern L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039339/
https://ncbi.nlm.nih.gov/pubmed/21135097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.198374
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