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Transition State Analysis of S. pneumoniae 5′-Methylthioadenosine Nucleosidase

Kinetic isotope effects (KIEs) and computer modeling are used to approximate the transition state of S. pneumoniae 5′-methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN). Experimental KIEs were measured and corrected for a small forward commitment factor. Intrinsic KIEs were obtained for...

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Autores principales: Singh, Vipender, Schramm, Vern L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2007
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2522316/
https://ncbi.nlm.nih.gov/pubmed/17298059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja065082r
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