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Characterizing DNA Methyltransferases With An Ultrasensitive Luciferase-Linked Continuous Assay
DNA (cytosine-5)-methyltransferases (DNMTs) catalyze the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the 5-position of cytosine residues and thereby silence transcription of regulated genes. DNMTs are important epigenetic targets. However, isolated DNMTs are weak catalysts an...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3115440/ https://ncbi.nlm.nih.gov/pubmed/21545095 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac200816m |
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