Inhibition and Structure of Toxoplasma gondii Purine Nucleoside Phosphorylase

The intracellular pathogen Toxoplasma gondii is a purine auxotroph that relies on purine salvage for proliferation. We have optimized T. gondii purine nucleoside phosphorylase (TgPNP) stability and crystallized TgPNP with phosphate and immucillin-H, a transition-state analogue that has high affinity...

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Main Authors: Donaldson, Teraya M., Cassera, María B., Ho, Meng-Chiao, Zhan, Chenyang, Merino, Emilio F., Evans, Gary B., Tyler, Peter C., Almo, Steven C., Schramm, Vern L., Kim, Kami
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2014
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060479/
https://ncbi.nlm.nih.gov/pubmed/24585883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/EC.00308-13
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