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Structural Determinants of the 5′-Methylthioinosine Specificity of Plasmodium Purine Nucleoside Phosphorylase

Plasmodium parasites rely upon purine salvage for survival. Plasmodium purine nucleoside phosphorylase is part of the streamlined Plasmodium purine salvage pathway that leads to the phosphorylysis of both purines and 5′-methylthiopurines, byproducts of polyamine synthesis. We have explored structura...

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Bibliografiske detaljer
Main Authors: Donaldson, Teraya M., Ting, Li-Min, Zhan, Chenyang, Shi, Wuxian, Zheng, Renjian, Almo, Steven C., Kim, Kami
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3885546/
https://ncbi.nlm.nih.gov/pubmed/24416224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0084384
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