Structural Determinants of the 5′-Methylthioinosine Specificity of Plasmodium Purine Nucleoside Phosphorylase

Plasmodium parasites rely upon purine salvage for survival. Plasmodium purine nucleoside phosphorylase is part of the streamlined Plasmodium purine salvage pathway that leads to the phosphorylysis of both purines and 5′-methylthiopurines, byproducts of polyamine synthesis. We have explored structura...

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Autori principali: Donaldson, Teraya M., Ting, Li-Min, Zhan, Chenyang, Shi, Wuxian, Zheng, Renjian, Almo, Steven C., Kim, Kami
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3885546/
https://ncbi.nlm.nih.gov/pubmed/24416224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0084384
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