Structural Determinants of the 5′-Methylthioinosine Specificity of Plasmodium Purine Nucleoside Phosphorylase

Plasmodium parasites rely upon purine salvage for survival. Plasmodium purine nucleoside phosphorylase is part of the streamlined Plasmodium purine salvage pathway that leads to the phosphorylysis of both purines and 5′-methylthiopurines, byproducts of polyamine synthesis. We have explored structura...

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Autors principals: Donaldson, Teraya M., Ting, Li-Min, Zhan, Chenyang, Shi, Wuxian, Zheng, Renjian, Almo, Steven C., Kim, Kami
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3885546/
https://ncbi.nlm.nih.gov/pubmed/24416224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0084384
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